I thought it was just her aging but now I think it al started when she started this medication. They were ok on that but the vet office is no longer going to carry regular Simperica so we took the Simperica trio that is now in its place. What are the side effects of Simparica Trio? 13 March he is also very lethargic and sitll not eating (even his favorite treats). Sorry man, that is horrible. Next day, he was suddenly 1000% worse, would not touch food, could not move. So now after $90.00 spent on three pills this month, I decide to look up the answers myself. I am going to try stopping the medication for a month to see if things improve. A heartworm test may be necessary in about six months (that's how long it takes heartworm larvae to mature enough to show up on a test). A few months back he started with a morning vomiting always on his empty tummy. He seemed okay with his next dose January 1, so we renewed the prescription, and I gave him the February dose too. have been seen after using medications in this class of drugs. Just gave my baby her first dose. Gave Simparica to my dog yesterday. Do not give extra or double doses. Currently, for Simparica, less than 0.01% of dogs taking this medication have experienced any neurologic side effects. Never again are my dogs getting oral medication for fleas & ticks. lola weighs about 9lbs. Some common side effects of various flea, tick, and worm preventatives include: Vomiting or diarrhea; Loss of appetite; Lethargy But im 99% sure the simparica is what caused it. Coincidence? He first started with seizures and losing weight in June after giving him Simparica. Vet thought was inner ear infection now thinking otherwise. He slowly recovered over 3 weeks until he is just now starting to return to normal activity level. Don't trust your vet, do your own research. My vets comment was I would know if his symptoms were related if at time for next dose his symptoms were gone they are gone. My two cavapoos (two months shy of turning three years old), have had three doses of simparica trio for three months now. Hi, Im wondering whats going on with your dog now? Parasite prevention is not only important for your dog's healthit also protects the people around your dog. I am so sorry to all of you and my heart goes out to you and your babies. So I did. Pet Bucket Ltd is a UK registered company|Company no: 08345021|BTC Bessemer Drive Stevenage, SG1 2DX UK. This is apparently not true and that's why the article never goes on to explain exactly why it only works on GABA receptors in fleas and ticks yet not affect the GABA receptors in your dog. My 5 year old, healthy Australian Shepherd had a check-up + boosters at the vet on January 24th. So sad as he was once a happy healthy dog with no prior health issues. I was reading that this drug enters the bloodstream quickly after giving it, and these symptoms and all the other reports have convinced me that I'm done using this on my pup. My 12 yr-old Chihuahua mix is losing his hair right above his nose. We started the medication on Dec. 1st and 3 days later it started with vomiting and loss of appetite. I will never use this stuff again and will tell anyone I see buying it or using it my story and yours too. I was blaming the tremors in his back legs on the fact that he has had both ACLs repaired. It really helped us to put this diarrhea condition in perspective. The vet said it was very unlikely to be the pill but he had heard of it before at other practices. Has anyone else experienced this? I am also very worried about him. Later in the fall I noticed some leg tremors when she squatted. She also started with ear infections. Same thing has happened to my 5 month old puppy after taking simparica. She's pacing and wants to eat grass. He is pissing a lot and often and drinking a lot of water. He has been barking a lot more than he used to. Hello! Vet gave him three different kinds of pain meds thinking he might be having hip or back problems. Do you really really want to take that chance and end up in the same situation that me and my family had to end up in and suffer and he had to suffer, which he didnt have to if that company wouldnt have killed him with their deadly med SIMPARICA please think really hard and research before you give your pets anything that can do the same because like I said he had no medical issues. Sorry but keeping it caged due to a suspected side effect is is uncalled for. $20.45 Trifexis Chewable Tablets for DogsRx Product Details Product Description Simparica Trio Chewable Tablets for Dogs works to prevent heartworms as well as treat lone star ticks, black-legged ticks, Gulf Coast ticks, American dog ticks, brown dog ticks, fleas, roundworms, and adult hookworms. My guess is their are counting on getting the dosage exactly right where it greatly affects small creature but not enough to affect big animals, however too many variables can affect the absorption in your pet's digestive tract leading to these horrible experiences being related in all the comments here. After doing more research on their monthly medication, I will no longer use Simparica Trio nor ever recommend it. I left a lot out but didnt want to make too lengthy post. Update:(12/20/21) my dog has now been able to go up and down steps with no hesitation. Gave our 23 month old Black Lab. Is your dog still having tremors? Hoping we dont have any more issues and will not be giving this again. If fact it specifically states on the product label "Not for use in humans". We took him to the animal er and they checked his vitals and he was fine. Now I have to pay $100's of dollars on meds to check her antibody and possibly put her on meds for life . He isnt losing weight but really looks horrible. If you havent already done so, please call the simparica trio phone number and report your dogs symptoms. This sure seems like this happening way too often . I gave him this medication last Thursday. Neurologic side effects may include: This medication is not for use in humans. I took him to the energy vet in the morning, he couldnt find any cause for pain, only he yelped a bit on his neck, they had trouble getting him in, he was yanking his neck around as he is afraid of the vet since getting fixed. After second pill, weve notice he has been a bit down for a couple days. These dog training tips will help you get started. He had no medical problems before this, and I took him to the vet every year he ended up dying two weeks later , I took him to the vet first they told me he wasnt gonna make it to leave him there and I told him no if he isnt gonna make it, hes going to pass away in my arms at home with me and his family why took him to a different vet not the same one I confronted the woman that gave me that medicine. Im now scared half to death. They did a blood test (this is literally 7 days later) and his ATL liver levels were off the charts at >2000. I've spoken to emergency vets and they say they are booked solid and that I need to just monitor her through the night. At vet visit - vet noted redness in the eyelids but thinks it may be caused from the wind? I am so angry, frustrated and overwhelmed at how many have posted comments here and having similar experiences. This medication works within the first few hours after administration to kill fleas present on your dog, and is dosed by weight, so it is important to use the correct-sized medication for your pet. Will never use again. When I bathe him the scabs fall off and I think, oh good, this problem is going away. Reading all of these comments I too think it is the drug that has caused his body to be toxic for him. I just wish I could find a vet who honestly loves my animals as much as I do. Never again will I be giving my pets any pharma meds. I realized it was from the simparica. Unlike Bravecto, Simparica hasn't been tested on pregnant, lactating, or breeding dogs. I have a completely different dog. Pyrantel Pamoate was first approved in 1977 for the treatment and . Thankfully there have been no other side effects. The vet recognized immediately that she was in severe neurogical distress. I do believe it caused her blindness. Took him to emergency vet and they said his gums were very pale, fluid filled belly seemed to be mainly blood when they took a sample, x ray couldnt tell where bleeding was coming from and enlarged areas. She has what is called knuckling. . He shakes and pants because of all the noises (turn signals, cars, radio, ect. Other signs may include: Lethargy Loss of appetite I just almost had a similar incident with my 16wk cavapoo. Our boy Axel had been on Heartgard his entire life. I took her home. My dog died from it after one dose within 24 hours. My last one lived to almost 15yrs old and I truly believe it was because I had him on Springtime Garlic tabs. He has bad allergies and oral works best. I have an appointment this Wednesday but not sure if Im going to keep it if the cough will go away eventually. It may or may not be the cause but I need to do everything in my power to bring my dog back to health. I wish I would have seen this site before I gave it my Matty. Also what are you looking at giving your dog as a seizure medication?? He was very anxious when I left him and picked him up. No more of this poison for him. She started it on 7/22. It was a mistake using this and I hope that in 4 weeks when it is out of her system, she will return to normal. My 2 1/2 mini goldendoodle has been on Simparica 10 days now. I just cross my fingers every day that she will get better after this is out of her system. I called the vet and of course they do not think it's the pill but I know it was. It has been 5 days since she had the 3 seizures in 24 hours. Im beyond heartbroken, shocked, and sad. The next day, we took him to his vet and had several tests ran (x-rays, bloodwork, etc.). Update June 7th. This is because drugs in the isoxazoline class have been associated with neurologic reactions including seizures, tremors, and ataxia in dogs with or without a history of neurologic disorders. Glad i held off on the free sample i was given! She has been taking the medicine since she was 6 months and she has gotten bigger so her dosage was increased. I have reached out to the company but one email bounced and the other was an online form. this is how Simparica works on insects who bite your dog. My veterinarian did not warn me of these and now my precious boxer is gone!!!!! Her heartbeat was more of a vibration than a beat and the vet wanted her to see a cardiologist. The reaction lasted less than 12 hours. I honestly think she had a reaction to the medication. Maybe? Shes now in the Er. Millions of dogs take flea and heartworm meds without side effects but that's not to say it doesn't happen or that an alternative would be safer. It may be that he is getting older as he is now one years old and he was neutered about three months ago. She has been taking Trifexis for years with no problem. Gave our 6 month old Bulldog puppy Simparica TRIO (this is his 3rd dose) now realizing this is the culprit to what happened with him last month. About 2 weeks later he had tremors, drooling, lethargic, uncoordinated, vomiting and was touch and go for a couple days. As I said, the first was a week after taking it, then the 2nd and third seizure happened at day 29. If it has been a long period of time since the last dose was given, you may see fleas temporarily during the missed time. Its crazy to think they dont recover and can die in a few months. They don't really have an answer for why this happens at all, or why some dogs get better and some don't. He has trouble raising his leg to urinate. I should have know it was a sign when he spat it out. It is important to work with your veterinarian to ensure the best flea/tick and heartworm prevention plan for your pets specific needs. Needless to say, we will no longer be giving this to our lab or our other dog. Almost $4k in medical labs, hospital, ultrasound etc no answers. Im wondering if anyone else has seen these types of symptoms. My vet never mentioned that puppies under 6months cannot be prescribed this medication. They watched him for a few hours and sent us on our way with a bill, again citing that he must have ate something. I keep praying she will recover and I feel so guilty for giving it to her. The day I gave it to him, he was up all night just randomly crying and yelping like he was in pain. We did not make the connection until today. His first was a week after taking his simparica. Some of the most common side effects of Simparica include vomiting, diarrhea, lethargy, (Read: Why is my poop black liquid?) Some years back my husband gave vet approved & sold oral flea/tic medication to each of our 2 Standard Poodles. I immediately filed a case number with Zoetis and informed my Vet as well as current Vet hospital he is being held at. Side-Effects Of Simparica Trio Tablets There are some mild side effects like Vomiting Diarrhea Loss of appetite Dog owners should be aware that these tablets are not suitable for all dogs. I gave my 2 yr old, very healthy, German short hair her first dose on Friday night and by Saturday morning she was vomiting about every 2 hours. He doesn't seem to be throwing up as much anymore, he did several times throughout the night though. She won't drink E walk or anything The doctor seemed to push this drug on me because the kombi guard was on back order. I brought him to the vet and they keep trying to say excessive water drinking isnt a side effect but its the only thing that is different that Ive given my pup. Doctor prescribed the salyien with some injunction but all are in vain..my labrador has same issues till datemy vet.not says anything about the side effect of the Simparica..i m now helpless..pls help me what should I do.. please help me to rid over itpls pls ..guide me. The day after administering drug he had two incapacitating seizures. We all want to protect our pets from fleas, ticks and the diseases they carry, but some treatments can come with nasty side effects. If you accidentally ingest a pet medication, call your physician or the national Poison Control Center hotline at 800-222-1222. Kind of ooze. Thankfully I have had experience with dealing with this with my kids and relatives so I dosed him with Benadryl. But he still is suffering from lethargy, polyuria and polydispia basically still drinks and pees non stop. Poor baby has had vomiting and diarrhoea ever since. Then she started having tremors. He is 80% its been 27 days since 2nd dose of Simparico.hoping we turned the corner! If anyone has discovered what can help please let me know. Fortunately, no seizures but dark yellow diarrhea and puppy has been drinking water like crazy and peeing even while asleep. Our dog had her first dose June 1st 2022 - diarrhea, scratching, excessive thirst. These side effects are usually mild and resolve on their own within a few days. Sarah thanks for your response! We talked with Zoetis (the manufacturer of Simparica) after the FDA's announcement to get some concrete numbers on the frequency of these adverse reactions. She has been diagnosed with thyroid problems and myocarditis. In isolated cases, however, dogs displayed more serious reactions such as tremors, muscle twitching, and seizures. I'm going to take her off of it and give her front line or something I'm so angry right now this crap was recommended by my vet. Now we are waiting for the verdict: whether its an infection in his bladder or stones. We hope this will solve our problems and he can live a healthy and happy life. So sorry you are having to go through this! This content shouldnt take the place of advice by your vet. Also - do NOT use Bravecto for females you intend to breed. Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching), polyuria (urinating more frequently), hyperactivity and polydipsia (drinking more water). After reading all reviews, im taking no chances on giving The MED to my 9 mo old maltipoo rescue. Her blood work came back fine. She has NEVER done that before. Simparica Trio (sarolaner, moxidectin, and pyrantel chewable tablets), is the first once-monthly, chewable tablet that delivers all-in-one protection from heartworm disease, ticks and fleas, roundworms and hookworms. I am terrified--wish I would of seen this sooner. This was the 2nd does I have him. only 7 yrs old and I still considered a puppy b/c of how active he was, we are on 8 days now of the lethargic not eating, goopy eyes - Dr says he has hyernaited disc but I have yet to see the xrays to confirm - blood work came back normail. And it looks like the liver and/or the kidney will not take it too. Stay safe! I gave my dog his first dose the first week of April. The most common side effects of Simparica in dogs are vomiting and diarrhea. It comes in a pack of six or 12, but veterinarians typically sell individual doses for growing puppies. My other Lab after 5 days started having severe diaherria (black at first, now golden) and now throwing up too. Simparica uses Sarolaner, which works by overstimulating the nervous system of the pests. Any suggestion? Bravecto 18. It is recommended to wash your hands after administering this medication. She has been on it for 6 months. Sarolaner is effective against the following tick species: Moxidectin is an antiparasitic drug in the macrocyclic lactone class. Some had fleas, some had heartworms, and some had roundworms. An neurological event took place again. Ive spent over $3,000 on vet bills for at least four visits to the ER and follow up lab work including X-rays. I used to use revolution but they dont cover ticks as well. before i even gave to my dog small doxie i asked the vet about it and they assured me it was safe since she was and i say was a healthy dog. 10 days after taking Simparica, she started having muscle tremors. I would say these changes may have happened more suddenly than just normal aging so I'm not going to give him this medication anymore. So far, the cost of diagnostic tests are about $700. They gave him IV glucose to raise his Potassium level. Simparica Trio covers the most common dog parasites and typically costs less than buying separate products. This junk needs to be pulled from the market. Simparica and Simparica Trio are available by prescription only. The revolutionary chewable tablet - Simparica is highly effective in eliminating fleas and various types of ticks. Sorry to hear about this happening to so many. Hoping for good news with your pup!! for flea and ticks? Mine has tremors once in a while and now I know why! Previously B was on Heartgard and Advantix worked well I guess we switch back. I would find another vet for a second opinion. All the swelling went down immediately and the itching went away too. Maybe dont have a dog. Today March 20 (8 week old) I get a message saying the puppy ate one of these pills that was for the bigger dog she already owned. She is shaking and panting heavy. She has had tremors, very lethargic, drinking lots of water. This medicine is making her shaky/tremor, anxious, and she is panting a ton. I to also gave my best friend Simparica as recommended by the vet. In a third field safety and effectiveness study, Simparica TRIO was administered to 120 dogs with roundworms. and now i'm on an hour by hour let's see if she will perk up. and you expect people to give this to their beloved pets? I'm so sorry. She was due to get the next dosage this week and i am choosing not to give it to her with the hopes that it will be out of her system and her Liver levels will go down. My dog is on a "health care plan" with my vet. Topical only for me from now on. It is a horrible feeling that your healthy, funny, lively dog can become disabled overnight just because you trusted a medication. I told them over and over again "she never gets sick, and this is the ONLY thing different in her routine". She went 11 days with no seizures and then had another gran mal. The vet doesn't seem to really want to blame it on Simperica Trio and wants to treat these symptoms which he says are life threatening. But unfortunately it's only a dog is the big Pharma tune. For the treatment and control of tick infestations with Amblyomma americanum (lone star tick) and Ixodes scapularis . She passed away soon after taking this medication. Hes very lethargic and constant vomiting! 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